Pursuing biomarkers research for a more efficient use of PARP inhibitors
نویسندگان
چکیده
The use of poly-adenosine diphosphate-ribose polymerase (PARP) inhibitors as maintenance therapy following response to platinum-based chemotherapy in frontline treatment and recurrent disease has dramatically changed the for advanced ovarian cancer. In treatment, olaparib
منابع مشابه
PARP inhibitors and more.
Polyadenosine diphosphate (ADP) ribose polymerase (PARP) lends a panoramic view to the inner mystery of protection of integrity of deoxyribonucleic acid (DNA) in a cell genome. They are a balancing part of an even more dynamic equilibrium of normalcy against daily assaults. PARP finds its companion candidates in other tumor suppressors, with the most prominent and glaring one being breast cance...
متن کاملRole of Biomarkers in the Development of PARP Inhibitors.
Defects in DNA repair lead to genomic instability and play a critical role in cancer development. Understanding the process by which DNA damage repair is altered or bypassed in cancer may identify novel therapeutic targets and lead to improved patient outcomes. Poly(adenosine diphosphate-ribose) polymerase 1 (PARP1) has an important role in DNA repair, and novel therapeutics targeting PARP1 hav...
متن کاملPARP inhibitors
Poly (ADP-ribose) polymerases, abbreviated as PARPs, are a group of familiar proteins that play a central role in DNA repair employing the base excision repair (BER) pathway. There about 17 proteins in this family out of which the primary nuclear PARPs are PARP-1, PARP-2, PARP-3, and tankyrases 1 and 2 (PARP-5a and -5b) .The PARP family members are known to engage in a wide range of cellular ac...
متن کاملPARP Inhibitors
Poly (ADP-ribose) polymerase (PARP) is a novel therapeutic target in cancer. Preclinical studies demonstrate that PARP inhibitors selectively kill BRCAdeficient cells and potentiate the effects of DNA-damaging agents. There are several PARP inhibitors in clinical development, including olaparib, iniparib, veliparib, PF01367338, and MK-4827. Phase II studies of single-agent olaparib demonstrate ...
متن کاملPARP Inhibitors for Cancer Therapy
Rucaparib is an inhibitor of nuclear poly (ADP-ribose) polymerases (inhibition of PARP-1 > PARP-2 > PARP-3), following a similar drug, Olaparib. It disrupts DNA repair and replication pathways (and possibly transcription), leading to selective killing of cancer cells with BRCA1/2 mutations. Rucaparib is approved for recurrent ovarian cancers with germline or somatic mutations in BRCA1/2.
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ژورنال
عنوان ژورنال: International Journal of Gynecological Cancer
سال: 2021
ISSN: ['1525-1438', '1048-891X']
DOI: https://doi.org/10.1136/ijgc-2021-002787